Lymphocytic Host Response and other Prognostic Factors in Early Stage Squamous Cell Carcinoma of Tongue: Retrospective Analysis from a Tertiary Cancer Center

Introduction The tongue is the most common site of malignancy in oral cavity, and squamous cell carcinoma commonest histology. prognosis remains unfavorable despite treatment, resulting higher mortality rates. Early stage a distinct entity primarily treated with either surgery or radiotherapy. Various factors have been implicated early carcinomas. main objective this study to access whether lymphocytic host response (LHR) other prognostic influence survival. Patients Methods data 129 patients Stage I II (T1-2, N0) cancer our institute from January 2012 December 2016 were retrospectively abstracted hospital case records. various clinical pathological recorded. Kaplan–Meier model was used for survival analysis. disease-free (DFS) overall (OS) respect LHR calculated. Results On multivariate analysis, lesion, comorbidities, habits, grade tumor, perineural infiltration (PNI) did not factor which found be significant DFS LHR. better who had ≥ 70% (strong LHR) when compared <70%(weak (p = 0.037). OS 0.608) 0.164) statistically significant. Conclusion weak less strong Larger studies are needed evaluate adding adjuvant therapy may benefit cancer.